Conotoxin peptide, Conotoxin anti-wrinkle peptide, Conotoxin botulinum toxin
Common Name | mu-conotoxin | ||
Molecular Weight | 2375.70 | ||
Density | 1.71±0.1 g/cm3 | Boiling Point | N/A |
Molecular Formula | C92H139N35O28S6 | Melting Point | N/A |
· Name: Mu-conotoxin
· INCI Name: Arginine/Lysine Polypeptide
· Molecular Formula: C92H139N35O28S6
Source and Extraction
Conotoxin peptide is a polypeptide substance extracted from the venom secreted by cone snails and obtained through artificial synthesis or biological simulation.
Mechanism of Action
· Blocking of Ion Channels: Conotoxin peptide can specifically block voltage-gated sodium channels, especially the Nav1.4 channel in muscles. It reduces the transmission of muscle contraction signals, thereby relaxing the muscles.
· Retention of Muscle Current Conduction: When the conotoxin peptide exerts its effect, it can retain 5% of the neuromuscular current conduction in the muscles, providing a natural rejuvenation effect and avoiding complete muscle stiffness and paralysis.
Efficacy Characteristics
· Significant Anti-wrinkle Effect: It can effectively improve dynamic wrinkles. By relaxing the muscles, it can instantly fade wrinkles, making the skin look younger.
· High Stability and Strong Penetrability: The conotoxin peptide is a highly folded peptide with a stable structure, which can strongly penetrate the skin and better exert its efficacy.
· High Safety: Relevant tests have shown that the conotoxin peptide has not exhibited any cytotoxicity, skin irritation, allergy, or eye irritation.
Application Fields
It is mainly applied in the cosmetics field. Many international brands such as Peter Thomas Roth, Natura Bissé, Revive, and Maria Galland have applied it in cosmetics. The product types include essence liquids, eye patches, forehead patches, eye creams, facial masks, etc.
Description μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of NaV1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties[1][2].
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Inflammation/Immunology
Target
NaV1.4 Channel[2]
References
[1]. Markgraf R, et al. Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br J Pharmacol. 2012 Oct;167(3):576-86.
[2]. Del Río-Sancho S, et al. Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. Int J Pharm. 2017 Feb 25;518(1-2):59-65.
